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MerCASBA: an updated and refined database of caspase substrates

Arthur Fridman, Irene Pak, Brent D Butts

    Apoptosis : an International Journal on Programmed Cell Death
    |January 22, 2013
    PubMed
    Abstract

    No abstract available in PubMed .

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    Caspases01:24

    Caspases

    Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.