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Updated: May 15, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Adjuvant methods to improve results of local bladder irrigations by chemotherapy for NMIBC
Yuval Freifeld1, Yoram Dekel, Avi Stein
1Department of Urology, Carmel Medical Centre, 7 Michal Street, Haifa, Israel. Yuvalfr@clalit.org.il
Abstract:
Non-muscle-invasive bladder cancer is characterized by frequent recurrences requiring repeated transurethral resections and carries a risk of progression to muscle-invasive disease. The routinely used, passive diffusion irrigation of the bladder with mitomycin C has achieved limited success in avoiding these events. We review two methods that may improve penetration of mitomycin C into the bladder wall, thus leading to better results in terms of recurrence rate and bladder preservation.
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