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Gallbladder and gastrointestinal motility after hemorrhagic shock
R Calabuig1, R E Seggerman, W A Weems
1Department of Surgery, University of Texas Medical School, Houston 77030.
Surgery
|May 1, 1990
Summary
Hemorrhagic shock temporarily impairs gallbladder and gastrointestinal motility, causing reduced slow-wave frequency and altered migrating motor complex (MMC) duration. Functionality returned to normal within 24 hours, suggesting transient ischemic damage.
Area of Science:
- Physiology
- Gastroenterology
- Surgical Research
Background:
- Hemorrhagic shock significantly impacts physiological functions.
- Gastrointestinal motility and gallbladder function are crucial for digestion and nutrient absorption.
Purpose of the Study:
- To investigate the effects of hemorrhagic shock on fasting gallbladder and gastrointestinal motility.
- To understand the temporal changes in these functions following shock and reinfusion.
Main Methods:
- Opossums underwent controlled hemorrhagic shock (30 mm Hg for 60 minutes) using a carotid catheter.
- Gallbladder volume and gastrointestinal electrical activity (slow-wave frequency, migrating motor complex) were measured before, immediately after, and 24 hours post-shock.
Main Results:
- Immediately after shock, slow-wave frequency decreased (antrum 40%, small bowel 25%), and migrating motor complex (MMC) duration shortened (p<0.05).
- Gallbladder volume increased (p<0.05), and MMC-associated volume fluctuations were absent.
- All measured parameters returned to baseline levels 24 hours after shock and reinfusion.
Conclusions:
- Hemorrhagic shock induces transient gallbladder dysfunction and altered gastrointestinal motility.
- Ischemic damage to the gastrointestinal tract is proposed as the underlying cause of these temporary alterations.