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Updated: May 15, 2026
Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
[Clinical and laboratory features of acute monocytic leukemia with B lymphoproliferative disorders]
Xue-Jing Chen1, Yan Liu, Gui-Qing Guo
1Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China.
Objective:
To identify the clinical and pathological features of acute myeloid leukemia with B lymphoproliferative disorders.
Methods:
The characteristics of 3 cases of acute monocytic leukemia with untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis were reported with literatures review.
Results:
The patients presented with a history of anemia, bleeding and/or fever. Acute monocytic leukemia was diagnosed by bone marrow morphology, cytochemistry and pathology studies. Immunophenotyping by flow cytometry analysis showed a significant population of absolute B-lymphocyte count of > 5×10(9)/L in a patients, similar to that of chronic lymphocytic leukemia.
Conclusions:
The association of acute monocytic leukemia and untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis was a rare event. The abnormal B lymphocytes was likely to be misdiagnosis. Thus, it was important to combine several kinds of laboratory studies, especially flow cytometry to identify this rare disorder.
