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Updated: May 15, 2026
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[Identification of a novel HLA-A allele A*11:01:37 by sequence-based typing]
Chun-Lai Zhang1, Gang Liang, Yi Zhang
1The Blood Centre of Linyi Red Cross Association of Shandong Province, Linyi, China.
Objective:
To identify a novel HLA-A allele in a Chinese Han individual.
Methods:
One mismatch was observed in HLA-A locus in HLA typing for CMDP donors using bi-allelic SBT kit. A confirmatory test for novel HLA allele was performed with mono-allelic SBT kit.
Results:
The DNA sequence was confirmed to be a novel HLA-A allele. There was 1 nucleotide differed from the closest matching HLA-A*11:01:01 at position 393(G→A), which resulting a change from GGG to GGA at codon 107, led to a silent mutation, conserving the amino acid Gly.
Conclusion:
A novel HLA-A allele was confirmed and officially named HLA-A*11:01:37 (Genbank accession number, JN209962) by the WHO Nomenclature Committee for Factors of the HLA System in January 2012.
