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Updated: May 15, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Bleeding complications after central line insertions: relevance of pre-procedure coagulation tests and institutional
T Kander1, A Frigyesi, J Kjeldsen-Kragh
1Department of Intensive and Perioperative Care, Skane University Hospital and Lund University, Lund, Sweden. thomas.kander@skane.se
Insights
Serious bleeding complications from central venous catheter insertion are rare in non-ICU patients. Large bore dialysis catheters may increase the risk of mild bleeding complications.
Area of Science:
- Medical Procedures
- Patient Safety
- Vascular Access
Background:
- Central venous catheter insertion is common in non-intensive care unit (ICU) settings.
- Understanding pre-procedural variables and risk factors for bleeding is crucial for patient safety.
Purpose of the Study:
- To identify pre-procedural variables associated with central venous catheter insertion.
- To assess the use of prophylactic blood components.
- To determine independent risk factors for bleeding complications outside the ICU.
Main Methods:
- Retrospective analysis of 1737 central venous catheter insertions in 1444 patients.
- Data collected included pre-procedural coagulation, blood component use, catheter type, and insertion site.
- Complications were compared with bleeding events documented in electronic charts.
Main Results:
- No serious bleeding complications were observed.
- Grade 2 bleeding (requiring prolonged compression) occurred in 0.9% of insertions.
- Insertion of large bore central dialysis catheters was an independent risk factor for bleeding.
- Conventional coagulation tests and procedural factors did not predict bleeding.
Conclusions:
- Serious bleeding complications are uncommon with central line insertions in non-ICU patients.
- Large bore catheter insertion is a potential independent risk factor for mild bleeding complications.
- Further research may refine risk assessment for these procedures.
Background:
The aim of this study was to map pre-procedural variables for insertion of a central venous catheter, prophylactic blood component use and to investigate whether any independent variable could be identified as an independent risk factor for associated bleeding complications in patients outside the intensive care unit.
Methods:
In this retrospective study, we investigated 1737 consecutive insertions of central venous catheters in 1444 patients in a large university hospital during 2009-2010. Pre-procedural coagulation status, blood component use, type of catheter, insertion site and complications during insertion were recorded and compared with bleeding complications documented on electronic charts.
Results:
No serious bleeding complications were recorded in connection with the insertion of central venous catheters. Sixteen of 1769 (0.9%) insertions caused grade 2 bleeding, defined as bleeding requiring prolonged compression at the insertion site. Insertion of a large bore central dialysis catheter was found to be an independent risk factor for bleeding complications. Neither conventional coagulation tests nor accidental arterial puncture or the number of needle passes could predict bleeding complications in this study.
Conclusion:
This retrospective study, in non-ICU patients, shows that serious bleeding complications in association with central line insertions are uncommon and that insertion of a large bore catheter is likely to be an independent risk factor for mild-bleeding complications in this population.
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