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[Efficacy of protein-free calf blood extract ophthalmic gel for diffuse punctate corneal epithelial defects]
Min-jie Chen1, Lan Gong, Xiao-di Qiu
1Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.
Objective:
To evaluate the clinical efficacy of protein-free calf blood extract ophthalmic gel for diffuse punctate corneal epithelial defects.
Methods:
36 patients (36 eyes) with diffuse punctate corneal epithelial defects were enrolled between Oct. 2008 and Apr. 2009 in outpatient clinic from Eye Ear Nose and Throat Hospital of Fudan University. Patients were randomized divided into protein-free calf blood extract ophthalmic gel group (the test group, 19 eyes) and recombinant bovine basic fibroblast growth factor ophthalmic gel group (the control group, 17 eyes). The drugs were delivered in both groups 4 times per day, one drop each time in the 14 days duration. Corneal staining, the tear break-up time, the Schirmer value and visual acuity were evaluated on the pre-delivery day and the post-delivery day 14.
Results:
On day 14, both the test group and control group had a significant decrease from baseline in corneal staining (the test group t = 5.7083, P = 0.0000 and the control group t = 4.5019, P = 0.0004, respectively). And improvements of corneal staining in the test group was more significant than that in the control group (t = 2.2712, P = 0.0296). Improvements were seen in BUT values in both group on day 14, as compared to baseline (the test group Z = 2.226, P = 0.0260 and the control group Z = 2.527, P = 0.0115, respectively). However, there was no significant difference between groups (Z = 1.336, P = 0.1815). As to the Schirmer value, there were neither difference within groups from baseline (the test group t = 0.4207, P = 0.6790 and the control group t = 1.1255, P = 0.2770, respectively). Nor between groups (t = 0.9830, P = 0.3325). And no obvious changes from baseline in visual acuity were observed in both groups (the test group Z = 1.897, P = 0.0578 and the control group Z = 1.786, P = 0.0741, respectively).
Conclusion:
The efficacy of protein-free calf blood extract ophthalmic gel is prior to recombinant bovine basic fibroblast growth factor ophthalmic gel in patients with diffuse punctate corneal epithelial defects.
