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Related Experiment Video

Updated: May 15, 2026

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

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Published on: April 26, 2018

Urinary bisphenol a concentration and thyroid function in Chinese adults.

Tiange Wang¹, Jieli Lu, Min Xu

¹Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.

Epidemiology (Cambridge, Mass.)

|January 23, 2013

Summary

This study found that higher levels of Bisphenol A (BPA) in urine were associated with altered thyroid function, including increased free triiodothyronine and decreased thyroid-stimulating hormone (TSH) in Chinese adults.

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Area of Science:

Endocrinology
Environmental Health
Epidemiology

Background:

Bisphenol A (BPA) is an endocrine disruptor with known effects on thyroid hormone receptors in animal studies.
Epidemiologic evidence on BPA's impact on human thyroid function is limited and inconsistent.
This study investigated the association between urinary BPA levels and thyroid function in a Chinese adult population.

Purpose of the Study:

To explore the relationship between urinary Bisphenol A (BPA) levels and thyroid function parameters.
To assess potential associations in a population-based cohort in Shanghai, China.

Main Methods:

A population-based study included 3394 adults aged 40 years and older in Shanghai, China.
Urinary BPA levels were analyzed in relation to thyroid function markers using multivariate linear regression.
Logistic regression was employed to examine associations stratified by thyroid function status.

Main Results:

Increased urinary BPA levels correlated with elevated free triiodothyronine and decreased thyroid-stimulating hormone (TSH) in both men and women.
Specifically, a one-quartile increase in BPA was linked to significant changes in these thyroid hormones.
High urinary BPA was associated with increased thyroid function (adjusted odds ratio = 1.71).

Conclusions:

Findings support previous research suggesting a link between Bisphenol A (BPA) exposure and altered thyroid hormones.
The study highlights potential endocrine-disrupting effects of BPA on thyroid function in humans.
As a cross-sectional study, causal relationships between BPA exposure and thyroid dysfunction cannot be definitively established.