Related Experiment Video
Updated: May 15, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
Rituximab in lymphomatoid granulomatosis
Carmen Hernández-Marqués1, Alvaro Lassaletta, Antonio Torrelo
1Departments of *Pediatric Hematology-Oncology †Dermatology ‡Radiology §Paediatrics ∥Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Background:
Lymphomatoid granulomatosis (LG) is an Epstein-Barr virus-associated, multisystemic disease that combines a granulomatous inflammatory process with lymphoproliferative potential. It is a rare disorder with a variable clinical presentation ranging from an indolent process to an aggressive B-cell lymphoma. Outcome is unpredictable, and a standard treatment has not yet been established. Cases treated with rituximab, an anti-CD20 monoclonal antibody, have been reported with variable results.
Observation:
We report on 2 children with LG treated with rituximab and review the literature. The first patient had good response but the second did not.
Conclusions:
Rituximab is a treatment option for LG.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents