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Updated: May 15, 2026

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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1
Takuya Terai1, Rie Tomiyasu, Tomoe Ota
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo, Japan.
Abstract:
TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first "turn-on" fluorescent probes for UGTs.
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