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Rewriting the bacterial glycocalyx via Suzuki-Miyaura cross-coupling
Christopher D Spicer1, Benjamin G Davis
1Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Chemical Communications (Cambridge, England)
|January 23, 2013
Abstract:
Suzuki-Miyaura cross-coupling has been used to couple novel carbohydrate-based boronic acids, site-selectively, to the surface of E. coli at an unnatural amino acid. In this way, benign metal-catalyzed cellular switching allowed modulation of interactions with biomolecular partners via prokaryotic O-glycosylation mimics.
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