Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Inflammation01:38

Inflammation

Overview
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Leveraging Type I Interferons: Exploring Pathogenesis and Therapeutic Strategies in Autoimmune Diseases.

Critical reviews in immunology·2026
Same journal

SLC2A1-Dependent Ketone Metabolism Regulates Tumor Progression and Immunotherapy Efficacy in Lung Adenocarcinoma.

Critical reviews in immunology·2026
Same journal

Knockdown of IGF2BP2 Inhibits THBS1 in Regulating the Progression of Oral Squamous Cell Carcinoma: An Integrative Analysis.

Critical reviews in immunology·2026
Same journal

Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and Host Immunity.

Critical reviews in immunology·2026
Same journal

Fusion Gene EPHB4-MET Driven by HOXA9 and Exerted Oncogenic Activity in Non-Small Cell Lung Cancer.

Critical reviews in immunology·2026
Same journal

Secreted Phosphoprotein 1 Represents a Therapeutic Target that Promotes the Progression of Ovarian Cancer by Driving M2 Macrophage Infiltration.

Critical reviews in immunology·2026

Related Experiment Video

Updated: May 14, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

The inflammatory process underlying atherosclerosis.

M Teresa Montero-Vega1

  • 1Department of Research in Biochemistry, Ramon y Cajal Institute for Health Research (IRYCIS), Ramon y Cajal University Hospital, Ctra. Colmenar, km 9, 28034-Madrid, Spain. teremonterovega@gmail.com

Critical Reviews in Immunology
|January 24, 2013
PubMed
Summary

Atherosclerosis, an inflammatory disease driven by cholesterol buildup, is increasingly understood through the lens of innate immunity. This review explores new insights into how innate immunity influences the pathogenesis of atherosclerosis.

More Related Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Related Experiment Videos

Last Updated: May 14, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Pathogenesis

Background:

  • Atherosclerosis is characterized by cholesterol accumulation in arteries, initiating an inflammatory response.
  • Recent advancements in innate immunity have significantly altered the understanding of inflammatory disease pathogenesis.
  • Innate immunity plays a crucial role in the initiation and progression of inflammatory disorders.

Purpose of the Study:

  • To review current concepts of innate immunity.
  • To re-evaluate the pathogenesis of atherosclerosis using an updated inflammatory perspective.
  • To integrate new findings on innate immunity with existing knowledge of atherosclerosis.

Main Methods:

  • Literature review of recent studies on innate immunity.
  • Analysis of existing data on atherosclerosis pathogenesis.
  • Synthesis of information to provide a novel inflammatory view.

Main Results:

  • Innate immunity provides critical insights into the inflammatory processes underlying atherosclerosis.
  • Understanding innate immune mechanisms offers a new framework for studying atherosclerosis.
  • The review highlights the complex interplay between cholesterol, inflammation, and innate immunity.

Conclusions:

  • Atherosclerosis pathogenesis is significantly influenced by innate immune responses.
  • Viewing atherosclerosis through the lens of innate immunity offers new therapeutic targets.
  • Further research into innate immunity is essential for understanding and treating atherosclerosis.