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An Efficient Single-Person Technique for Milk Sampling from Laboratory Mice
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Does milk cause constipation? A crossover dietary trial.

Elesa T Crowley1, Lauren T Williams, Tim K Roberts

  • 1Department of Rural Health NSW, University of Newcastle, Tamworth, NSW 2340, Australia. elesa.crowley@hnehealth.nsw.gov.au

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|January 24, 2013
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Summary
This summary is machine-generated.

Replacing cow's milk with soy milk may resolve chronic functional constipation (CFC) in children. However, different types of cow's milk beta-casein did not show a significant effect on constipation.

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutrition

Background:

  • Chronic Functional Constipation (CFC) is a common pediatric condition.
  • Cow's milk protein is frequently implicated in pediatric functional gastrointestinal disorders.

Purpose of the Study:

  • To determine if replacing cow's milk protein with soy protein resolves CFC in children.
  • To investigate the impact of specific cow's milk beta-casein variants (A1 and A2) on CFC.

Main Methods:

  • Two crossover trials were conducted involving children diagnosed with CFC.
  • Trial 1 compared cow's milk and soy milk.
  • Trial 2 compared cow's milk beta-casein A1 and A2.

Main Results:

  • In Trial 1, 9 out of 9 participants who completed the soy milk intervention experienced constipation resolution (p < 0.05).
  • In Trial 2, constipation resolution rates were 81% during washout, 79% for beta-casein A2, and 57% for beta-casein A1, with no statistically significant differences.
  • Trial 1 indicated an association between CFC and cow's milk consumption.

Conclusions:

  • Soy milk replacement appears effective in resolving CFC in susceptible children.
  • Specific cow's milk beta-casein types (A1 vs. A2) did not demonstrate a significant differential effect on CFC.
  • An unidentified component in cow's milk, common to both A1 and A2 variants, may contribute to CFC in some children.