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Updated: May 14, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Top-cited articles on hyperbaric oxygen therapy published from 2000 to 2010
Ching-Hsing Lee1, Lan Lee, Kun-Ju Yang
1Hyperbaric Oxygen Therapy Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. lancetlee@gmail.com
Hyperbaric oxygen therapy (HBO2T) research has grown significantly over the past decade. Key study areas include stroke, radiation injury, carbon monoxide, and wounds, with the US leading publications.
Area of Science:
- Medical research
- Biomedical engineering
- Clinical applications
Background:
- Hyperbaric oxygen therapy (HBO2T) is a recognized medical specialty with diverse clinical uses.
- Evaluating research trends is crucial for guiding future scientific endeavors in HBO2T.
- This study analyzes highly cited articles to understand the focus of HBO2T research.
Purpose of the Study:
- To identify and analyze the most frequently cited HBO2T articles.
- To determine the primary research directions and trends in HBO2T over a 10-year period.
- To provide insights for researchers in the field of hyperbaric oxygen therapy.
Main Methods:
- Searched PubMed for "Hyperbaric oxygen" articles published between January 2000 and November 2010.
- Utilized Google Scholar to track citation counts for retrieved articles.
- Identified the top 100 most-cited articles and analyzed publication year, author nationality, journal, study field, and research style.
Main Results:
- A total of 2,362 HBO2T-related articles were identified, showing an increasing publication trend.
- The United States contributed over half (52%) of the top-cited articles.
- Leading research areas included stroke (20 articles), radiation injury (11), carbon monoxide (10), and wounds (9), collectively representing 50% of the top-cited studies.
Conclusions:
- Scientific publications in HBO2T have shown a consistent increase over the last decade.
- Major research focuses include stroke, radiation injury, carbon monoxide poisoning, and wound healing.
- The United States remains a significant contributor to the field of HBO2T research.
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