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Published on: June 6, 2025
Acute promyelocytic leukemia-associated thrombosis
Hung Chang1, Ming-Chung Kuo, Lee-Yung Shih
1Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
Acta Haematologica
|January 25, 2013
Summary
Acute promyelocytic leukemia (APL) patients face significant thrombosis risks, often overlooked. This study found ischemic stroke and catheter-related thrombosis were common in Taiwanese APL patients, with no lab markers predicting these events.
Area of Science:
- Hematology
- Oncology
- Vascular Medicine
Background:
- Acute promyelocytic leukemia (APL) patients exhibit a dual risk of bleeding and thrombosis.
- APL-associated thrombosis is often underrecognized compared to bleeding complications.
Purpose of the Study:
- To investigate the incidence and characteristics of thrombosis in acute promyelocytic leukemia patients.
- To identify potential risk factors and clinical outcomes associated with APL-related thrombosis.
Main Methods:
- Retrospective analysis of 127 APL cases over 20 years.
- Collection and comparison of coagulation profiles, including WBC, platelet counts, PT, aPTT, fibrinogen, and DIC scores.
- Analysis of clinical outcomes and risk factors in patients with and without thrombosis.
Main Results:
- Ten cases (7.9%) of APL-associated thrombosis were identified.
- Cerebral infarction (5 cases) and catheter-related thrombosis (5 cases) were the most frequent events.
- No significant association was found between laboratory coagulation parameters and thrombosis development.
Conclusions:
- APL patients are susceptible to thrombosis, necessitating clinical vigilance beyond bleeding risks.
- Ischemic stroke and catheter-related thrombosis represent a unique pattern in Taiwanese APL patients.
- Current laboratory coagulation parameters do not reliably predict thrombosis in APL.
