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Anti-inflammatory lignans from the fruits of Acanthopanax sessiliflorus
Dae-Young Lee1, Kyeong-Hwa Seo, Rak-Hun Jeong
1Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Korea.
Molecules (Basel, Switzerland)
|January 25, 2013
Abstract:
A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
