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Updated: May 14, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Finding the evidence to support evidence-based practice.
1University of Medicine and Dentistry School of Nursing, Newark, USA.
The 6S Model helps clinicians efficiently find the best evidence for patient care. This evidence-based practice approach integrates research findings with patient values and clinical expertise.
Area of Science:
- Clinical Practice
- Evidence-Based Medicine
- Information Science
Background:
- Practicing evidence-based medicine requires integrating evidence, patient preferences, and clinical expertise.
- Clinicians often struggle to efficiently locate the best available evidence for practice.
Purpose of the Study:
- To introduce and explain the 6S Model for evidence acquisition.
- To guide clinicians in efficiently searching for and evaluating evidence.
- To enhance the application of evidence-based practice in clinical settings.
Main Methods:
- Explanation of the 6S Model hierarchy for evidence retrieval.
- Discussion of the strengths and weaknesses of various evidence types.
- Guidance on assessing evidence trustworthiness and clinical relevance.
Main Results:
- The 6S Model provides a structured approach to evidence searching.
- Understanding evidence types aids in critical appraisal.
- Clinicians can improve evidence integration into patient care.
Conclusions:
- The 6S Model facilitates efficient access to best evidence for clinicians.
- Effective use of evidence enhances patient care outcomes.
- Practitioners play a crucial role in ensuring evidence relevance and trustworthiness.
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