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Updated: May 14, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

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Published on: November 26, 2013

The THRombolysis and STatins (THRaST) study.

Manuel Cappellari1, Paolo Bovi, Giuseppe Moretto

  • 1SSO Stroke Unit, U.O. Neurologia d.O., DAI di Neuroscienze, Azienda Ospedaliera Universitaria Integrata, Italy. manuel_cappellari@libero.it

Neurology
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

Statin use during acute stroke treatment after IV thrombolysis improved patient outcomes. This included better neurologic function and reduced risks of deterioration and death.

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Intravenous (IV) thrombolysis is a critical treatment for acute ischemic stroke.
  • The role of statin therapy initiated during the acute phase of stroke following IV thrombolysis requires further elucidation.
  • Understanding the impact of early statin administration on stroke outcomes is crucial for optimizing patient care.

Purpose of the Study:

  • To evaluate the effect of administering statins in the acute phase after IV thrombolysis on stroke outcomes.
  • To assess both efficacy and safety measures related to early statin use in stroke patients.

Main Methods:

  • A multicenter study analyzed prospectively collected data from 2,072 patients treated with IV thrombolysis.
  • Efficacy outcomes included neurologic improvement and major neurologic improvement at 7 days, and favorable/excellent functional outcomes at 3 months.
  • Safety outcomes assessed were 7-day neurologic deterioration, symptomatic intracerebral hemorrhage, and 3-month mortality.

Main Results:

  • Statin use was significantly associated with improved neurologic function at 7 days (OR 1.68) and major neurologic improvement (OR 1.43).
  • Patients receiving statins showed a higher likelihood of favorable functional outcomes at 3 months (OR 1.63).
  • Early statin administration correlated with a reduced risk of neurologic deterioration (OR 0.31) and death (OR 0.48).

Conclusions:

  • Initiating statin therapy in the acute phase after IV thrombolysis appears to positively impact stroke outcomes.
  • Early statin use may lead to better short-term neurologic recovery and long-term functional status.
  • These findings suggest that statins could be a beneficial adjunct therapy in acute stroke management post-thrombolysis.