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Updated: May 14, 2026

High-definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
Synchrotron-based Biological Microspectroscopy: From the Mid-Infrared through the Far-Infrared Regimes
L M Miller1, G D Smith, G L Carr
1Brookhaven National Laboratory, National Synchrotron Light Source, Upton, NY 11973 USA.
Abstract:
Infrared radiation from synchrotron storagerings serves as a high-brightness source fordiffraction-limited microspectroscopy inboth the mid- and far-infrared spectralranges. Mid-infrared absorption, due to localvibrational modes within complex molecules,is shown to be sensitive to small chemicalchanges associated with certain diseases.Farinfrared modes are believed to result from thefolding or twisting of larger, morecomplex molecules. The ability for thesynchrotron source to perform microscopy ata frequency of 1 THz is demonstrated.
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