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Autosomal similarity revealed by eukaryotic genomic comparison
1Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 PR China.
Journal of Biological Physics
|January 25, 2013
Summary
Eukaryotic autosomes show greater differences between species than within a species. This suggests intra-species autosomal random shuffling, not frequent lateral gene transfer, shaped their evolution.
Area of Science:
- Genomics
- Bioinformatics
- Evolutionary Biology
Background:
- Understanding the evolutionary relationships and diversity of eukaryotic autosomes is crucial.
- Previous studies have explored gene sequences and protein functions, but a quantitative comparison across species is needed.
Purpose of the Study:
- To quantitatively describe eukaryotic autosomes.
- To determine inter- and intra-species differences in gene sequences, protein functions, and DNA sequences.
- To propose a hypothesis explaining the observed patterns.
Main Methods:
- Applied the Proteome-vector method (sequence similarity) and the function of degree of disagreement (FDOD) method (function similarity).
- Analyzed autosomes from nine eukaryotic species.
- Compared autosomal characteristics quantitatively.
Main Results:
- Autosomal differences within a species were consistently less than differences between species.
- Eukaryotic autosomes exhibit high similarity within a species.
- Significant differences were observed between autosomes of different species.
Conclusions:
- Eukaryotic autosomes are highly conserved within species but divergent between species.
- Proposed the 'intra-species autosomal random shuffling' hypothesis to explain these findings.
- Concluded that lateral gene transfer (LGT) likely played a limited role in eukaryotic autosome evolution.
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