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Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
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Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

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Closed-Loop, Multichannel Experimentation Using the Open-Source NeuroRighter Electrophysiology Platform.

Jonathan P Newman1, Riley Zeller-Townson, Ming-Fai Fong

  • 1Laboratory for Neuroengineering, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine Atlanta, GA, USA.

Frontiers in Neural Circuits
|January 25, 2013
PubMed
Summary

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A wireless, 60-channel, AI-enabled neurostimulation platform.

Brain stimulation·2025

NeuroRighter is an open-source platform for real-time, closed-loop multichannel electrophysiology. Enhanced features simplify complex experiments, making advanced neural research more accessible and affordable.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Single neuron feedback control techniques like voltage clamp are crucial for understanding neural dynamics.
  • Existing multichannel systems lack native support for real-time feedback, limiting network-level research.
  • Open-source solutions are needed to bridge the gap between accessibility and advanced electrophysiology.

Purpose of the Study:

  • To present substantial enhancements to the open-source NeuroRighter platform.
  • To improve real-time, closed-loop multichannel electrophysiology capabilities.
  • To simplify the design and execution of sophisticated neural interfacing experiments.

Main Methods:

  • Development of an enhanced NeuroRighter platform featuring a redesigned desktop application.
Keywords:
closed-loopelectrophysiologymicro-electrode arraymulti-electrodemultichannelnetworkopen-sourcereal-time

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  • Implementation of a new stimulation subsystem for arbitrary stimulation patterns.
  • Integration of low-latency data servers and a new plugin-based API for closed-loop protocols.

    • Main Results:

    • The enhanced NeuroRighter platform offers 64 channels of stimulation and recording at a low cost (~$10,000).
    • New features include arbitrary waveform generation and low-latency data streaming.
    • A flexible plugin API allows easy integration of custom closed-loop protocols.

    Conclusions:

    • The enhanced NeuroRighter platform significantly advances accessible, real-time multichannel electrophysiology.
    • The system empowers researchers to design and conduct complex closed-loop experiments with ease.
    • NeuroRighter provides a powerful, cost-effective solution for neural interfacing research.