A wireless, 60-channel, AI-enabled neurostimulation platform

Closed-loop neuromodulatory therapies require devices that can decode ongoing brain states and deliver multi-site stimulation.

We describe the Smart Neurostimulation System (SNS), a cranially mounted implant with 60 configurable recording/stimulation channels, inductive power, and onboard spectral-feature classification. In three freely-moving sheep, we streamed local-field potentials and conducted two parameter-sweep experiments.

Cross-validated movement classifiers achieved an average AUC exceeding 0.95. Increasing stimulation amplitude and frequency produced post-stimulation elevations in α-band (8-12 Hz) and γ-band (78-82 Hz) power at most target locations.

The SNS unifies high-density sensing, real-time brain state decoding, and programmable closed-loop stimulation in a single device, demonstrating behavioral-state prediction and parameter-dependent neuromodulation in vivo.

These findings establish a preclinical foundation for biomarker-guided stimulation targeting distributed cortical networks underlying memory and cognition.