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Published on: July 5, 2021
Skull base inverted papilloma: a comprehensive review.
Shafik N Wassef1, Pete S Batra, Samuel Barnett
1Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA ; McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4 ; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 2B4.
Skull base inverted papilloma (IP) is a rare tumor known for recurrence and destruction. This review familiarizes clinicians with IP, focusing on skull base invasion and intradural extension.
Area of Science:
- Neurosurgery
- Otolaryngology
- Pathology
Background:
- Skull base inverted papilloma (IP) is an uncommon tumor.
- IP exhibits a high recurrence rate, local destructive potential, and association with malignancy.
- Understanding IP's behavior is crucial for neurosurgeons.
Purpose of the Study:
- To provide a comprehensive review of skull base inverted papilloma.
- To focus on IP's potential for skull base invasion and intradural extension.
- To familiarize clinicians with the clinical aspects of this unusual disease.
Main Methods:
- Comprehensive literature review from 1947 to September 2010.
- Synthesis of published reports, studies, and reviews.
- Focus on diagnostic imaging and surgical approaches.
Main Results:
- IP can invade the skull base and extend intradurally.
- Modern medical imaging aids in assessing tumor extent for surgical planning.
- Radical excision is challenging, often incomplete.
Conclusions:
- Successful management requires complete resection of affected mucosa via open, endoscopic, or combined approaches.
- Radiotherapy and chemotherapy have specific indications.
- Multicenter randomized trials are needed for optimal research.
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