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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

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Postoperative radiotherapy for ependymoma.

Jinhong Jung¹, Wonsik Choi, Seung Do Ahn

¹Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Radiation Oncology Journal

|January 25, 2013

Summary

Postoperative radiotherapy for ependymoma shows good survival rates, with tumor grade being a key prognostic factor. Recurrence primarily occurs at the primary tumor site, suggesting advanced radiotherapy techniques for high-risk patients.

Keywords:

Anaplastic ependymoma Ependymoma Histologic grade Radiotherapy Stereotatic radiosurgery

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Area of Science:

Neuro-oncology
Radiation Oncology

Background:

Ependymoma is a primary tumor of the central nervous system.
Postoperative radiotherapy is a common treatment modality for ependymoma.

Purpose of the Study:

To evaluate failure patterns, survival rates, toxicity, and prognostic factors in patients with ependymoma treated with postoperative radiotherapy.

Main Methods:

Retrospective review of 30 patients with ependymoma who received surgery and postoperative radiotherapy.
Analysis of tumor grade (WHO II vs. III), radiation dose (median 52.8 Gy), and follow-up duration (median 51 months).

Main Results:

Overall survival (OS) and progression-free survival (PFS) at 5 years were 66.7% and 56.1%, respectively.
Tumor grade was a significant prognostic factor for OS and PFS.
Recurrence occurred in 46.7% of patients, with most being in-field recurrences.

Conclusions:

Postoperative radiotherapy for ependymoma yields favorable survival outcomes.
Histologic grade is a critical prognostic indicator.
Further investigation into intensity-modulated radiotherapy or stereotactic radiosurgery is warranted for high-risk patients, particularly anaplastic ependymoma.