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Published on: January 26, 2024
Expression of DJ-1 proteins in placentas from women with severe preeclampsia
Han-Sung Kwon1, Han-Sung Hwang, In-Sook Sohn
1Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.
Objective:
Lately, DJ-1 has been identified as a novel mediator of hypoxia-induced cellular responses. The aim of this study was to determine the difference of DJ-1 expression in the placentas of women with normal and preeclamptic pregnancies.
Study Design:
DJ-1 mRNA expression was quantified by quantitative reverse transcription polymerase chain reaction (RT-PCR). Also, immunoperoxidase and immunofluorescent staining for DJ-1 was performed on 11 normal and 12 preeclamptic placental tissues.
Results:
The expression of mRNA of DJ-1 was significantly higher in the study group than in the control group. The immunoreactivity was especially higher in the syncytiotrophoblast of preeclamptic placentas compared to the control group.
Conclusion:
Overexpression of the DJ-1 protein in the placentas of severe PE patients is thought to be a causative or compensatory mechanism in response to hypoxia, and this finding might contribute to a better understanding of the pathophysiology of preeclampsia.
