Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Methylxanthines01:24

Antiasthma Drugs: Methylxanthines

Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic investigation of the association between maternal dietary patterns and offspring ADHD.

Molecular psychiatry·2026
Same author

Comorbidity of asthma and attention deficit hyperactivity disorder in childhood: causal, shared early-life risk factors, or shared genetic liability?

International journal of epidemiology·2026
Same author

Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort.

Health science reports·2026
Same author

Quantifying the impact of early life growth adversity on later life health.

Communications medicine·2025
Same author

The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.

European respiratory review : an official journal of the European Respiratory Society·2025
Same author

Quantifying the impact of early-life growth adversity on later-life health.

medRxiv : the preprint server for health sciences·2025
Same journal

Image-guided pediatric airway endoscopy: A review.

Paediatric respiratory reviews·2026
Same journal

Bronchoscopic and interventional management of tracheobronchomalacia in children with bronchopulmonary dysplasia: a review of evidence.

Paediatric respiratory reviews·2026
Same journal

Hand in glove: New imaging techniques and airway endoscopy.

Paediatric respiratory reviews·2026
Same journal

Bronchopulmonary dysplasia associated pulmonary hypertension: implications across the lifespan.

Paediatric respiratory reviews·2026
Same journal

How to monitor response to biologics in children with severe asthma.

Paediatric respiratory reviews·2026
Same journal

Moving the goalposts from symptom control to preventing airway remodeling in preschool asthma.

Paediatric respiratory reviews·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Acetaminophen and asthma.

A John Henderson1, Seif O Shaheen

  • 1School of Social and Community Medicine, University of Bristol, UK. a.j.henderson@bris.ac.uk

Paediatric Respiratory Reviews
|January 26, 2013
PubMed
Summary
This summary is machine-generated.

Acetaminophen use in pregnancy and infancy is linked to childhood asthma. More research, including randomized trials, is needed to confirm this association and guide interventions for at-risk children.

More Related Videos

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
05:56

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

Related Experiment Videos

Last Updated: May 14, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
05:56

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

Area of Science:

  • Pediatric medicine
  • Epidemiology
  • Pharmacology

Background:

  • Acetaminophen is a common pain and fever reliever for children and pregnant women.
  • Epidemiological studies consistently link acetaminophen use to asthma symptoms in children.
  • Evidence suggests a connection between prenatal/infant acetaminophen exposure and later childhood asthma, even after accounting for confounders.

Purpose of the Study:

  • To review the evidence linking acetaminophen use to asthma.
  • To highlight the need for causal inference through randomized trials.
  • To inform the development of interventions for children at risk of asthma.

Main Methods:

  • Review of epidemiological studies on acetaminophen use and asthma.
  • Analysis of confounding factors and dose-response relationships.
  • Identification of research gaps and recommendations for future studies.

Main Results:

  • Substantial epidemiological evidence supports an association between acetaminophen use and asthma.
  • The association appears robust to confounders and may be dose-dependent.
  • Confounding by indication remains a consideration, but evidence is compelling.

Conclusions:

  • The epidemiological data strongly suggests a link between acetaminophen and childhood asthma.
  • Establishing causation through randomized controlled trials is crucial.
  • Further research is needed to develop targeted interventions for children at risk.