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Updated: May 14, 2026

A Tactile Automated Passive-Finger Stimulator (TAPS)
19:44

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Published on: June 3, 2009

Thick and thin fingers point out Turing waves.

Andrew D Economou, Jeremy B A Green

    Genome Biology
    |January 26, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Mouse genetics and computer simulations reveal that digit number and width are controlled by a Turing-type mechanism. Distal Hox genes play a key role in modulating this developmental process, influencing limb patterning.

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    Last Updated: May 14, 2026

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    Published on: June 3, 2009

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    Published on: December 15, 2010

    Area of Science:

    • Developmental biology
    • Genetics
    • Computational biology

    Background:

    • Limb development is a complex process involving precise spatial and temporal gene regulation.
    • Understanding the genetic basis of digit patterning is crucial for developmental biology.

    Purpose of the Study:

    • To investigate the underlying mechanism controlling digit number and width during limb development.
    • To explore the role of distal Hox genes in modulating developmental periodicity.

    Main Methods:

    • Utilized mouse genetics to study limb development.
    • Employed computer simulations to model developmental processes.
    • Analyzed the function of distal Hox genes in digit formation.

    Main Results:

    • Demonstrated a Turing-type mechanism controlling digit number and width.
    • Showcased how distal Hox genes modulate periodicity in limb development.
    • Provided evidence for a quantitative model of digit patterning.

    Conclusions:

    • The study elucidates a novel mechanism for digit patterning.
    • Distal Hox genes are critical regulators of limb development periodicity.
    • Integrates genetic and computational approaches to understand developmental processes.