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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Estrogen synthesis and signaling pathways during aging: from periphery to brain
1Center for Hormone Advanced Science and Education (CHASE), Roskamp Institute, Sarasota, FL 34243, USA.
Trends in Molecular Medicine
|January 26, 2013
Summary
Estrogens are key female hormones with vital roles beyond reproduction. This review explores tissue-specific estrogen synthesis, signaling, and their impact on diseases like cardiovascular conditions, osteoporosis, Alzheimer's, and Parkinson's.
Area of Science:
- Endocrinology
- Molecular Biology
- Neuroscience
Background:
- Estrogens are primary female sex hormones with critical reproductive and non-reproductive functions.
- Estrogen synthesis occurs in various non-reproductive tissues, influencing diverse physiological actions.
- Understanding tissue-specific estrogen effects is crucial for comprehending various health conditions.
Purpose of the Study:
- To comprehensively review tissue and cell-specific estrogen synthesis and estrogen receptor signaling.
- To elucidate the distribution and signaling pathways of estrogen receptors.
- To explore the roles of estrogens in health and disease, including cardiovascular diseases, osteoporosis, Alzheimer's disease (AD), and Parkinson disease (PD).
Main Methods:
- Literature review focusing on estrogen synthesis and metabolism.
- Analysis of estrogen receptor distribution and signaling mechanisms.
- Examination of estrogen functions and their association with specific disorders.
Main Results:
- Estrogens exhibit diverse actions mediated by tissue-specific synthesis and receptor signaling.
- Estrogen signaling pathways are implicated in the pathophysiology of major diseases.
- Detailed understanding of estrogen's role in cardiovascular health, bone density, and neurodegenerative diseases.
Conclusions:
- Tissue-specific estrogen synthesis and signaling are fundamental to diverse physiological processes.
- Estrogen dysregulation contributes to significant health disorders, including cardiovascular diseases, osteoporosis, AD, and PD.
- This review offers insights into tissue-specific estrogen effects, enhancing understanding of their roles in disease.
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