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Updated: May 14, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Primary antiphospholipid syndrome and panhypopituitarism: a unique presentation
Bárbara Santos Pires da Silva1, Camila Bonin, Cristina Bellotti Formiga Bueno
1Biomedicine, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.
Abstract:
Lymphocytic hypophysitis (LH) has been described previously in systemic lupus erythematosus (1.3%), Sjögren's syndrome (0.8%). Lymphocytic hypophysitis (LH) is rarely associated with rheumatic diseases, although three cases of pituitary disease associated with antiphospholipid syndrome (APS) have been described. Here, we report a possible association between APS and LH for the first time. A 34-yr-old woman with primary APS presented with polyuria, polydipsia, hypernatremia and impaired vision. Her hormone profile was compatible with panhypopituitarism, and sellar magnetic resonance imaging (MRI) depicted a normal pituitary gland with a thickened and displaced stalk and infundibulum portion. Hormone replacement was started, and the patient experienced a good clinical evolution.
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