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Related Experiment Video

Updated: May 14, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Oral hyaline ring granuloma.

Paolo Boffano¹, Cesare Gallesio, Paola Campisi

¹Division of Maxillo facial Surgery, Head and Neck Department, San Giovanni Battista Hospital, University of Turin, Turin, Italy. paolo.boffano@gmail.com

The Journal of Craniofacial Surgery

|January 26, 2013

Summary

Hyaline ring granuloma is a rare oral lesion with debated causes, possibly linked to food particles or degenerated tissues. This article presents a case and reviews existing literature on its etiology.

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Area of Science:

Oral pathology
Histopathology

Background:

Hyaline ring granuloma is a rare oral lesion.
Its etiology is unclear and controversial, with proposed theories including vegetable origin or degeneration of blood vessels, collagen, or serum proteins.

Observation:

Histologically characterized by "hyaline rings" (palely eosinophilic structureless material).
Multinucleated giant cells are present around and within these hyaline rings.

Findings:

Presents a case study of hyaline ring granuloma.
Reviews the existing literature on the pathogenesis of this oral lesion.

Implications:

Contributes to understanding the differential diagnosis of oral lesions.
Highlights the need for further research into the etiology of hyaline ring granuloma.