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Middle ear effusion in patients with sinonasal cancer treated by surgery with or without radiotherapy
Luca Oscar Redaelli de Zinis1, Giovanni Parrinello, Alberto Schreiber
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia School of Medicine, Brescia, Italy. redaelli@med.unibs.it
Objective:
To identify the prevalence and risk factors of eustachian tube dysfunction after surgery for sinonasal cancer by observing the occurrence of middle ear effusion.
Study Design:
Historical cohort study.
Setting:
Academic university hospital.
Subjects And Methods:
Clinical records of 112 patients surgically treated for sinonasal cancer over a 16-year period were evaluated. Initial bivariate analysis was followed by a multivariate logistic regression model.
Results:
The best model included 2 variables: posterior extension of surgical resection (nasopharynx, soft palate, eustachian tube, pterygomaxillary fossa, parapharyngeal space) with an odds ratio of 5.662 (95% confidence interval [CI], 1.877-9.447) and postoperative radiotherapy with an odds ratio of 8.691 (95% CI, 4.187-13.194).
Conclusion:
Despite the limited number of patients, the study gives a prediction of middle ear effusion based on 2 well-defined factors: surgical resection of anatomic structures involved in tubal function and adjuvant radiotherapy.
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