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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Related Experiment Video

Updated: May 14, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Lung function indices for predicting mortality in COPD.

Afroditi K Boutou1, Dinesh Shrikrishna, Rebecca J Tanner

  • 1NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.

The European Respiratory Journal
|January 26, 2013
PubMed
Summary
This summary is machine-generated.

Simple spirometry may not be sufficient for predicting survival in chronic obstructive pulmonary disease (COPD). Measuring carbon monoxide transfer factor offers additional prognostic information beyond spirometry for COPD patients.

Related Experiment Videos

Last Updated: May 14, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Clinical Epidemiology

Background:

  • Chronic obstructive pulmonary disease (COPD) presents significant morbidity and mortality.
  • Identifying key prognostic factors in COPD is crucial for patient management.
  • The sufficiency of simple spirometry for predicting COPD outcomes remains uncertain.

Purpose of the Study:

  • To determine which lung function parameters provide the most prognostic information in COPD outpatients.
  • To assess if standard spirometry is adequate for predicting survival in COPD.
  • To evaluate the added prognostic value of lung volumes, gas transfer, and arterial blood gases.

Main Methods:

  • Prospective data collection of COPD outpatients undergoing comprehensive lung function testing.
  • Inclusion of spirometry, lung volumes, carbon monoxide transfer factor, and arterial blood gases.
  • Multivariate Cox proportional hazard modeling to identify independent predictors of mortality.

Main Results:

  • Out of 604 patients, 229 (37.9%) died during a median follow-up of 83 months.
  • Carbon monoxide transfer factor (% predicted), age, and arterial oxygen partial pressure were independently associated with mortality.
  • Higher carbon monoxide transfer factor was linked to significantly lower mortality risk.

Conclusions:

  • Carbon monoxide transfer factor measurement provides prognostic information beyond spirometry in COPD.
  • Routine inclusion of gas transfer measurements in COPD follow-up may improve survival prediction.
  • Age and arterial oxygen levels are also critical prognostic indicators in COPD.