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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: May 14, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Aptamer-based nanoparticles for cancer targeting.

Lucas Torres Miranda Sá1, Suzanne Simmons, Sotiris Missailidis

  • 1Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Drug Targeting
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Mesoporous silica nanoparticles functionalized with aptamers show promise for cancer targeting. These non-cytotoxic nanoparticles are uniform in size and suitable for further applications, particularly in nuclear medicine.

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Published on: June 23, 2020

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Mesoporous silica nanoparticles (MSNs) are increasingly utilized for targeted cancer therapy.
  • Combining MSNs with biological compounds offers a promising drug delivery system for oncological diseases.

Purpose of the Study:

  • To develop and characterize mesoporous silica nanoparticles (SBA-15) functionalized with MUC-1 aptamers for cancer targeting.

Main Methods:

  • Synthesis of mesoporous silica (SBA-15).
  • Functionalization of SBA-15 with MUC-1 targeting aptamers.

Main Results:

  • Characterization confirmed uniform mesoporous silica nanoparticles with a size range of 50-100 nm.
  • Cytotoxicity studies indicated no adverse effects associated with the nanoparticles.

Conclusions:

  • The aptamer-loaded mesoporous silica nanoparticle model is highly functional for cancer targeting.
  • Potential for widespread application, especially in nuclear medicine, pending further research.