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Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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Related Experiment Video

Updated: May 14, 2026

Experimental Human Pneumococcal Carriage
07:47

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Published on: February 15, 2013

Sweet's syndrome triggered by pneumococcal vaccination.

Ana Filipa Pedrosa1, Paulo Morais, Ana Nogueira

  • 1Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Alameda Professor Hernani Monteiro, Porto, Portugal. anabastospedrosa@gmail.com

Cutaneous and Ocular Toxicology
|January 29, 2013
PubMed
Summary

Sweet's syndrome, a neutrophilic dermatosis, can be triggered by vaccines. This report details a rare case of Sweet's syndrome following pneumococcal vaccination, specifically the 13-valent conjugate vaccine.

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Area of Science:

  • Dermatology
  • Immunology
  • Vaccinology

Background:

  • Sweet's syndrome, a form of acute febrile neutrophilic dermatosis, is characterized by specific diagnostic criteria.
  • While vaccines are recognized as potential triggers, documented cases linking them to Sweet's syndrome are infrequent.
  • Neutrophilic dermatoses encompass a group of inflammatory skin conditions.

Observation:

  • A patient presented with symptoms consistent with Sweet's syndrome.
  • The onset of symptoms occurred subsequent to receiving a pneumococcal vaccination.
  • This specific vaccine was the 13-valent pneumococcal conjugate vaccine.

Findings:

  • The case confirms a potential association between pneumococcal vaccination and the development of Sweet's syndrome.
  • This represents the second reported instance of pneumococcal vaccine-induced Sweet's syndrome.
  • It is the first documented case linked to the 13-valent conjugate pneumococcal vaccine.

Implications:

  • Highlights the importance of considering vaccination history in patients presenting with Sweet's syndrome.
  • Suggests a need for further investigation into the immunogenic mechanisms linking pneumococcal vaccines to Sweet's syndrome.
  • Contributes to the understanding of rare adverse events following immunization.