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Lewis acid-promoted ketene-alkene [2 + 2] cycloadditions

Christopher M Rasik1, M Kevin Brown

  • 1Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47401, United States.

Journal of the American Chemical Society
|January 29, 2013
PubMed
Summary

Lewis acids catalyze ketene-alkene [2 + 2] cycloadditions, accelerating reactions and yielding versatile cyclobutanones. This method offers inverse diastereoselectivity, providing new synthetic routes and mechanistic insights.

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