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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

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Related Experiment Video

Updated: May 14, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Human inflammatory dendritic cells induce Th17 cell differentiation.

Elodie Segura1, Maxime Touzot, Armelle Bohineust

  • 1INSERM U932, 26 rue d'Ulm, 75005 Paris, France.

Immunity
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Inflammatory dendritic cells (DCs) are a distinct subset found in human inflammatory fluids. These DCs, potentially monocyte-derived, drive T helper 17 (Th17) cell responses, crucial for immunity.

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Related Experiment Videos

Last Updated: May 14, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key immune regulators.
  • Several human DC subsets exist in noninflammatory states.
  • The DC compartment in inflammation remains poorly understood.

Purpose of the Study:

  • Characterize DCs in human inflammatory fluids.
  • Determine their relationship to other immune cells.
  • Investigate their role in T cell responses.

Main Methods:

  • Phenotypic analysis of DCs from inflammatory fluids.
  • Transcriptome analysis for gene expression profiling.
  • Co-culture assays with autologous T cells.

Main Results:

  • A distinct DC population was identified in inflammatory fluids.
  • These DCs share gene signatures with in vitro monocyte-derived DCs.
  • Inflammatory DCs, but not macrophages, induced Th17 cell differentiation and IL-17 production.

Conclusions:

  • Inflammatory DCs represent a unique human DC subset.
  • They are likely monocyte-derived.
  • These cells are involved in initiating and sustaining Th17 cell responses.