Resistive training improves insulin sensitivity after stroke.

Area of Science:

• Neurology
• Metabolic Health
• Exercise Physiology

Background:

• Insulin resistance is common in stroke survivors, increasing the risk of cardiovascular disease.
• Cardiovascular conditions are a primary cause of mortality in this population.

Purpose of the Study:

• To investigate the impact of unilateral resistive training (RT) on insulin sensitivity in individuals who have experienced a stroke.
• To assess changes in insulin and glucose metabolism following a 12-week RT program.

Main Methods:

• 10 participants with hemiparetic gait post-stroke underwent 12 weeks of progressive, high-intensity RT.
• Evaluations included strength testing (1-RM), oral glucose tolerance tests (OGTT), and hyperglycemic clamps.
• Body composition was assessed using dual-energy x-ray absorptiometry.

Main Results:

• Significant increases in leg press and leg extension strength were observed.
• Fasting insulin levels decreased by 23%, while fasting glucose remained unchanged.
• Insulin sensitivity, measured by hyperglycemic clamp, improved by 31% post-training.
• Insulin response during the clamp tests showed significant reductions in both first and second phases.

Conclusions:

• Resistive training (RT) demonstrates potential for reducing hyperinsulinemia in stroke survivors.
• This study provides preliminary evidence that RT can improve insulin sensitivity after a stroke.
• RT may be a beneficial intervention for managing metabolic complications in this population.