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Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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Related Experiment Video

Updated: May 14, 2026

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
08:24

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Published on: February 28, 2017

Pluripotent stem cells and gene therapy.

Pavel Simara1, Jason A Motl, Dan S Kaufman

  • 1Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.

Translational Research : the Journal of Laboratory and Clinical Medicine
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cells, including induced pluripotent stem cells (iPSCs), offer a versatile source for cell therapies. Gene modification of iPSCs shows promise for treating genetic diseases through autologous transplantation.

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Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFP
08:25

Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFP

Published on: April 3, 2012

Related Experiment Videos

Last Updated: May 14, 2026

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
08:24

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Published on: February 28, 2017

Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFP
08:25

Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells (iPSCs) Using Retroviral Vector with GFP

Published on: April 3, 2012

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Genetic Engineering

Background:

  • Human pluripotent stem cells (hPSCs) are a key resource for clinical research and therapies.
  • Induced pluripotent stem cells (iPSCs) enable patient-specific cell generation.
  • Advancements in gene editing offer potential for correcting genetic defects in iPSCs.

Purpose of the Study:

  • To review recent progress in human iPSC generation and gene modification techniques.
  • To discuss the potential of genetically corrected iPSCs for treating genetic disorders.
  • To explore challenges and future directions for clinical translation of hPSC-based therapies.

Main Methods:

  • Review of current literature on iPSC generation methods.
  • Analysis of gene modification strategies applied to iPSCs.
  • Examination of preclinical data for hematological, neuronal, and muscular disorders.

Main Results:

  • Preclinical studies demonstrate successful correction of disease mutations in iPSCs.
  • Genetically corrected iPSCs show potential for autologous transplantation in various disorders.
  • Significant progress has been made in iPSC generation and gene editing technologies.

Conclusions:

  • Human iPSCs hold significant therapeutic potential, particularly when genetically corrected.
  • Overcoming remaining obstacles is crucial for clinical application of iPSC-based therapies.
  • Future research will focus on refining techniques and addressing safety concerns for widespread use.