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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Related Experiment Video

Updated: May 14, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

[Blood disease and bone].

Masahiro Abe1

  • 1Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.

Clinical Calcium
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Hematological disorders like multiple myeloma can cause significant bone destruction by increasing bone resorption and decreasing bone formation. Other disorders, such as POEMS syndrome, manifest as osteosclerotic lesions.

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Area of Science:

  • Hematology
  • Oncology
  • Bone Biology

Context:

  • Hematological malignancies frequently impact bone health.
  • Multiple myeloma and primary bone lymphoma are primary bone marrow tumors.
  • POEMS syndrome and primary myelofibrosis present with osteosclerotic lesions.

Purpose:

  • To describe the distinct bone lesions associated with various hematological disorders.
  • To elucidate the mechanisms of bone destruction and formation in these conditions.

Summary:

  • Multiple myeloma and primary bone lymphoma induce bone destruction by stimulating osteoclastogenesis (via RANKL) and inhibiting osteoblast differentiation.
  • These processes lead to rapid bone loss.
  • POEMS syndrome and primary myelofibrosis are characterized by osteosclerotic lesions.
  • Hypercalcemia is linked to advanced adult T-cell leukemia/lymphoma and multiple myeloma.

Impact:

  • Understanding these bone manifestations is crucial for diagnosis and management.
  • This knowledge aids in developing targeted therapies for bone complications in hematological cancers.
  • Highlights the complex interplay between hematological disorders and skeletal integrity.