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An image processing approach to characterizing choroidal blood flow.

G J Klein1, R H Baumgartner, R W Flower

  • 1Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20707.

Investigative Ophthalmology & Visual Science
|April 1, 1990
PubMed
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New algorithms analyze indocyanine green (ICG) dye angiography images to reveal detailed human choroidal blood flow dynamics. This method offers a unique way to characterize choroidal circulation for potential clinical applications.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Indocyanine green (ICG) dye angiography visualizes human choroidal blood flow.
  • Current methods yield low-contrast images difficult to interpret due to pigmented tissue and complex choroidal vasculature.
  • Conventional image processing enhances vessel appearance but lacks dynamic blood flow information.

Purpose of the Study:

  • To develop novel algorithms for characterizing human choroidal blood flow dynamics.
  • To overcome limitations of conventional ICG angiography image interpretation.
  • To establish a method for routine characterization of choroidal circulation.

Main Methods:

  • Development of image processing algorithms using personal computer hardware.

Related Experiment Videos

  • Acquisition of digital images from film negatives or direct video digitization.
  • Application of time-sequence analysis to generate 2D curves and 3D surfaces representing blood flow dynamics.

    • Main Results:

    • Algorithms characterize choroidal circulation by unique 3D surfaces reflecting blood flow dynamics.
    • The method successfully conserves spatial distribution of blood flow across the entire choroidal area.
    • Demonstrated unique correspondence between derived 3D surfaces and individual choroidal circulations.

    Conclusions:

    • This is the first approach to routinely characterize human choroidal circulation with spatial blood flow dynamics.
    • The generated 3D surfaces may aid in discriminating between normal and abnormal choroidal circulations.
    • Potential for improved clinical utility of ICG angiography in ophthalmology.