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Dermatomyositis associated with multifocal lipoatrophy.

C Commens1, P O'Neill, G Walker

  • 1Skin and Cancer Foundation, Ashley Centre, Westmead N.S.W., Australia.

Journal of the American Academy of Dermatology
|May 1, 1990
PubMed
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Juvenile dermatomyositis can present with lipoatrophy, a condition causing localized fat loss. This case report details a 10-year-old boy with both conditions, highlighting a previously undocumented association.

Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Pathology

Background:

  • Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy affecting children.
  • Lipoatrophy is characterized by localized loss of subcutaneous fat.
  • The association between JDM and lipoatrophy is not well-established.

Observation:

  • A 10-year-old male presented with multiple, asymmetric lipoatrophy lesions.
  • The lipoatrophy developed without preceding signs of inflammation.
  • Skin biopsy confirmed lobular panniculitis.

Findings:

  • This case represents the first documented instance of lipoatrophy occurring in conjunction with juvenile dermatomyositis.
  • Histopathological examination revealed lobular panniculitis as the underlying cause of lipoatrophy in this patient.

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  • The absence of preceding inflammation in the lipoatrophy lesions is a notable clinical observation.

    • Implications:

    • This finding expands the spectrum of cutaneous manifestations associated with juvenile dermatomyositis.
    • It suggests that lobular panniculitis should be considered in the differential diagnosis of lipoatrophy in children, particularly those with or at risk for JDM.
    • Further research is warranted to elucidate the potential pathomechanisms linking JDM and lipoatrophy.