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Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
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Updated: May 14, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
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Published on: February 22, 2014

Palmitoylation, pathogens and their host.

Mathieu Blanc1, Sanja Blaskovic, F Gisou van der Goot

  • 1Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, CH-1015 Lausanne, Switzerland. mathieu.blanc@epfl.ch

Biochemical Society Transactions
|January 30, 2013
PubMed
Summary

S-palmitoylation, a reversible protein lipid modification, is crucial for pathogen survival and infection. Pathogens exploit host S-palmitoylation machinery to advance their life cycles.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathogen Biology

Background:

  • S-palmitoylation is the only reversible post-translational lipid modification.
  • This modification imparts unique biochemical and functional properties to proteins.
  • Viral proteins are known to be palmitoylated, but its role in other pathogens is increasingly recognized.

Purpose of the Study:

  • To review the involvement of S-palmitoylation in infections caused by viruses, bacteria, and parasites.
  • To illustrate how pathogens manipulate host S-palmitoylation machinery.

Main Methods:

  • Literature review of existing studies on S-palmitoylation and host-pathogen interactions.

Main Results:

  • S-palmitoylation plays a critical role for various pathogens throughout their life cycle.
  • Pathogens have evolved mechanisms to hijack the host's S-palmitoylation machinery.

Conclusions:

  • S-palmitoylation is a key factor in the pathogenesis of diverse infectious agents.
  • Understanding pathogen manipulation of host S-palmitoylation offers potential therapeutic targets.