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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

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Related Experiment Video

Updated: May 14, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination.

M Blaha1, M Kostal, M Lanska

  • 12nd Department of Internal Medicine, Charles University School of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. blaham@email.cz

Atherosclerosis. Supplements
|January 30, 2013
PubMed
Summary
This summary is machine-generated.

Mean platelet volume (MPV) decreased significantly after LDL-cholesterol elimination therapy in familial hypercholesterolemia patients. This finding suggests MPV may serve as a marker for successful LDL-lowering treatment.

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Cholesterol Efflux Assay
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Published on: March 6, 2012

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Mean platelet volume (MPV) is increasingly recognized as a cardiovascular risk factor.
  • Larger platelets are associated with higher reactivity.
  • A decrease in MPV following LDL-lowering therapy could indicate treatment success.

Purpose of the Study:

  • To investigate changes in mean platelet volume (MPV) after extracorporeal LDL-cholesterol elimination.
  • To evaluate MPV as a potential marker for therapeutic efficacy in familial hypercholesterolemia.

Main Methods:

  • MPV was measured in 12 patients with severe familial hypercholesterolemia before and after LDL apheresis (immunoapheresis or cascade filtration).
  • 95 paired samples were analyzed over 4 years.
  • LDL apheresis utilized Lipopak 400 adsorbers or Evaflux 4A filters.

Main Results:

  • Mean platelet volume decreased significantly from 10.891 fl to 10.478 fl (p = 0.036) after LDL-cholesterol elimination procedures.
  • No correlation was found between MPV and age, sex, platelet count, or therapy duration.
  • MPV remained unchanged in patients with age-related macular degeneration treated with rheohemapheresis.

Conclusions:

  • Mean platelet volume is an accessible parameter that may be overlooked.
  • MPV changes can inform the assessment of patients with familial hypercholesterolemia.
  • MPV can serve as a simple, cost-effective marker for the efficacy of extracorporeal LDL-cholesterol elimination therapy.