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Regular lipoprotein apheresis maintains residual cardiovascular and microvascular function in patients with advanced

M Reimann1, U Julius, S R Bornstein

  • 1Autonomic and Neuroendocrinological Laboratory, Dept of Neurology, University Hospital Carl Gustav Carus, Dresden Fetscherstr 74, 01307 Dresden, Germany. manja.reimann@uniklinikum-dresden.de

Atherosclerosis. Supplements
|January 30, 2013
PubMed

Insights

Lipoprotein apheresis (LA) did not sustain short-term cardiovascular improvements long-term. However, regular LA treatment maintained existing cardiovascular function in patients with advanced atherosclerotic disease.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Vascular Biology

Background:

  • Lipoprotein apheresis (LA) is a treatment for managing hyperlipidemia.
  • Short-term studies indicate LA can improve cardiovascular function.
  • The long-term sustainability of these benefits is not well-established.

Purpose of the Study:

  • To assess the long-term effects of regular lipoprotein apheresis on cardiovascular function.
  • To determine if initial beneficial cardiovascular effects are maintained over one year of treatment.

Main Methods:

  • Seventeen regular lipoprotein apheresis users were evaluated over one year.
  • Endothelial and autonomic functions were assessed at baseline and one year.
  • Microvascular function (retinal vessels) and autonomic regulation (blood pressure, heart rate) were measured.

Main Results:

  • Acute improvements in cardiovagal and endothelial function were not observed at one year.
  • Baroreflex sensitivity showed improved recovery after orthostatic challenge.
  • Compromised autonomic and microvascular function did not worsen over the treatment year.

Conclusions:

  • Regular lipoprotein apheresis treatment does not sustain initial short-term cardiovascular improvements.
  • However, it appears to maintain residual cardiovascular function in patients with advanced atherosclerotic disease over time.
Abstract

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