Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Development of the Limb Synovial Joints

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.

Endocrine reviews·2026

Same author

Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease.

Genome research·2026

Same author

Stage-Specific Collagen V Knockdown Reveals Temporal Control of Fibrillogenesis, Remodeling, and Mechanics in Tendon Healing.

International journal of molecular sciences·2026

Same author

An Ex Vivo Model of Laser-Induced Microdamage to Study Tendon Repair.

Tissue engineering. Part A·2026

Same author

Loss of type III collagen has limited effect on tendon healing in young adult mice.

Matrix biology : journal of the International Society for Matrix Biology·2026

Same author

Aged Tendons Have Impaired Mechanosensitivity and Lower Thresholds for Injury under Dynamic Compression.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: May 14, 2026

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Structure-function relationships of postnatal tendon development: a parallel to healing.

Brianne K Connizzo¹, Sarah M Yannascoli, Louis J Soslowsky

¹McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA.

Matrix Biology : Journal of the International Society for Matrix Biology

|January 30, 2013

Summary

This summary is machine-generated.

This review explores tendon structure-function relationships, comparing development and healing. Understanding collagen fiber alignment and mechanical properties is key for improving tendon repair strategies.

More Related Videos

Murine Flexor Tendon Injury and Repair Surgery

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

Related Experiment Videos

Last Updated: May 14, 2026

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Murine Flexor Tendon Injury and Repair Surgery

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

Area of Science:

Biomedical Engineering
Connective Tissue Biology
Musculoskeletal Research

Background:

Tendon injuries are common, impacting mobility and quality of life.
Current treatments for tendon healing have limitations.
Understanding the fundamental structure-function relationships in tendons is crucial for developing effective therapies.

Purpose of the Study:

To review recent research on tendon structure-function relationships.
To highlight parallels between tendon development and tendon healing.
To examine the role of extracellular matrix components in tendon mechanics.

Main Methods:

Literature review focusing on structure-function relationships in tendon.
Analysis of mechanical behavior in mature, developing, and healing tendons.
Examination of the roles of collagen, proteoglycans, and cross-links.

Main Results:

Collagen fiber re-alignment and fibril uncrimping are key mechanical determinants during development and healing.
Developing tendon mechanics offer insights into healing tendon processes.
Extracellular matrix composition significantly influences tendon mechanical behavior.

Conclusions:

Recreating developmental structure-function relationships is essential for augmenting injured tendons.
Future research should focus on mimicking natural tendon development for enhanced healing.
A deeper understanding of matrix components can guide novel therapeutic strategies.