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Related Experiment Video

Updated: May 14, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Internet-based behavioral activation and acceptance-based treatment for depression: a randomized controlled trial.

Per Carlbring¹, Malin Hägglund, Anne Luthström

¹Department of Psychology, Stockholm University, Stockholm, Sweden. per@carlbring.se

Journal of Affective Disorders

|January 30, 2013

Summary

This study provides initial evidence that internet-delivered behavioral activation (BA) with acceptance and commitment therapy (ACT) components effectively reduces depression symptoms. The online treatment showed a large effect size compared to a waiting list control.

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Last Updated: May 14, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Area of Science:

Psychiatry and Behavioral Sciences
Digital Health Interventions
Mental Health Treatment

Background:

Internet-based cognitive behavior therapy (CBT) for depression is established, but studies on internet-delivered behavioral activation (BA) are lacking.
No prior research has investigated internet-delivered BA incorporating acceptance and commitment therapy (ACT) components.

Purpose of the Study:

To develop and evaluate the efficacy of an internet-delivered BA treatment combined with ACT components.
To compare the novel internet-delivered treatment against a waiting list control group for depression.

Main Methods:

Eighty general public participants were randomized to either the 8-week internet-delivered BA+ACT treatment or a waiting list control.
The intervention included interactive online modules, a CD-ROM for mindfulness/acceptance exercises, and weekly therapist feedback.
Assessments were conducted post-treatment and at a 3-month follow-up using the Beck Depression Inventory II (BDI-II) and secondary measures.

Main Results:

A large between-group effect size (d=0.98) was observed on the BDI-II post-treatment.
Remission rates (BDI-II ≤ 10) were significantly higher in the treated group (25%) compared to the control group (5%).
Low dropout rates (N=2) were observed, with participants completing an average of 5.1 out of 7 modules.

Conclusions:

Initial evidence suggests that internet-delivered BA with ACT components is effective in reducing depressive symptoms.
The study's primary limitation is the lack of an active control group, preventing determination of specific component effectiveness.