Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Facial Feedback Hypothesis

Facial Feedback Hypothesis

Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role of...

Muscles for Facial Expressions

Muscles for Facial Expressions

The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Evidence Is In: Devices and Biologics Reshaping Modern Dermatology.

Dermatologic clinics·2026

Same author

A quantitative definition for poorly soluble particles.

Particle and fibre toxicology·2026

Same author

Prospective Single-Site Open-label Study Assessing Safety and Efficacy of Poly-L-Lactic Acid for Temple Volume Loss.

Journal of drugs in dermatology : JDD·2026

Same author

Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data.

Clinical research in cardiology : official journal of the German Cardiac Society·2025

Same author

Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data.

Clinical research in cardiology : official journal of the German Cardiac Society·2025

Same author

A Single-Center, Open-Label, Prospective Study of a 589/1319 nm Dual Wavelength Laser for the Treatment of Facial Hyperpigmentation.

Journal of drugs in dermatology : JDD·2024

Search research articles

Related Experiment Video

Updated: May 14, 2026

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

A novel approach to structural facial volume replacement.

Neil S Sadick¹, Suveena Manhas-Bhutani, Nils Krueger

¹Department of Dermatology, Weill Cornell Medical College, Cornell University, 911 Park Avenue, Suite 1A, New York, NY 10075, USA. nssderm@sadickdermatology.com

Aesthetic Plastic Surgery

|January 30, 2013

Summary

A comprehensive approach to facial rejuvenation combines volume restoration, skin protection, cell turnover, collagen stimulation, and muscle control for natural anti-aging results. This holistic strategy addresses the entire face, moving beyond isolated treatments.

More Related Videos

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Published on: December 9, 2025

Related Experiment Videos

Last Updated: May 14, 2026

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Published on: December 9, 2025

Area of Science:

Aesthetic Medicine
Dermatology
Anti-aging Research

Background:

Aging facial anatomy and physiology necessitate a shift towards comprehensive rejuvenation.
Current approaches are evolving from isolated wrinkle treatments to holistic facial framework considerations.

Purpose of the Study:

To present an overview of a comprehensive method for addressing facial aging.
To detail a holistic strategy integrating various modalities for facial cosmesis.

Main Methods:

Key components include sunscreens, antioxidants, epidermal turnover promotion (chemical peels, microdermabrasion), collagen stimulation (light, ultrasound, RF), and muscle control (botulinum toxin).
Available fillers and volumizers include hyaluronic acid (HA), autologous fat, calcium hydroxylapatite (CaHA), and poly-L-lactic acid (PLLA).
A novel bimodal, trivector technique for structural volume restoration is presented, combining fat pad injections and PLLA for panfacial lipoatrophy.

Main Results:

The combination of fillers, toxins, energy-based devices, and surgical procedures offers a comprehensive approach.
This integrated strategy aims to forestall the facial aging process.

Conclusions:

A holistic paradigm integrating multiple treatment modalities provides more natural and effective facial rejuvenation outcomes.
Combining fillers, toxins, energy-based technologies, and surgical procedures can achieve superior results compared to monotherapy.