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Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Considerations for sequencing analyses of pancreatic cancer progression and metastasis

Alvin Makohon-Moore1, Christine A Iacobuzio-Donahue

  • 1Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 30, 2013
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...