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Colistin inhalation monotherapy for ventilator-associated pneumonia of Acinetobacter baumannii in prematurity

Chia-Hao Kang1, Chih-Min Tsai, Tin-Hsin Wu

  • 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Pediatric Pulmonology
|January 30, 2013
PubMed

Insights

Inhaled colistin effectively treated ventilator-associated pneumonia (VAP) in premature infants caused by Acinetobacter baumannii. This treatment showed no adverse events, suggesting its potential for VAP management in neonates.

Area of Science:

  • Neonatal intensive care
  • Infectious disease management
  • Pediatric pulmonology

Background:

  • Ventilator-associated pneumonia (VAP) in neonates caused by Acinetobacter baumannii presents a growing challenge with high mortality.
  • Limited data exists on inhaled colistin monotherapy for VAP in preterm infants.

Purpose of the Study:

  • To evaluate the efficacy and safety of aerosolized colistin as monotherapy for VAP caused by Acinetobacter baumannii in preterm infants.

Main Methods:

  • Retrospective evaluation of eight preterm infants (25-36 weeks gestation) with VAP due to Acinetobacter baumannii.
  • Treatment involved inhaled colistin (1,000,000 IU twice daily) for an average of 9.1 days.
  • Five isolates were multi-drug resistant Acinetobacter baumannii (MDR-AB), all sensitive to colistin.

Main Results:

  • Complete cure achieved in all preterm infants, with successful eradication of Acinetobacter baumannii from airway secretions.
  • No clinical or laboratory adverse events were observed during colistin treatment.

Conclusions:

  • Aerosolized colistin monotherapy is a viable treatment option for VAP caused by Acinetobacter baumannii in preterm infants.
  • Further controlled studies are recommended to confirm these findings and establish definitive treatment guidelines.
Abstract

Keywords:
Acinetobacter baumanniicolistininhalationpre-term

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