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[Ferritin in myeloproliferative diseases]
1Evangelisches Waldkrankenhaus Spandau, Akademisches Lehrkrankenhaus, Freien Universität Berlin.
Medizinische Klinik (Munich, Germany : 1983)
|March 15, 1990
Summary
Serum ferritin levels are normal in early stages of chronic granulocytic leukemia (CGL) but significantly increase during blastic crisis, correlating with disease severity and leukemic blast ferritin synthesis.
Area of Science:
- Hematology
- Oncology
- Biochemistry
Context:
- Investigated serum ferritin levels in various myeloproliferative neoplasms.
- Focused on chronic granulocytic leukemia (CGL) and its subtypes.
- Compared ferritin concentrations across different disease phases and types.
Purpose:
- To determine the role of serum ferritin in CGL progression.
- To correlate ferritin levels with specific cytomorphological subtypes of blastic crisis.
- To understand the source of elevated ferritin in CGL.
Summary:
- Serum ferritin is normal in chronic phase CGL, polycythemia vera, osteomyelosclerosis, and megakaryocytic myelosis.
- Blastic crisis of CGL shows significantly elevated serum ferritin, with levels varying by cytomorphological type (M1/M2 highest).
- Elevated intracellular ferritin in leukemic blasts correlates with increased serum ferritin, suggesting increased synthesis by blasts.
Impact:
- Provides a biomarker for CGL progression and blastic crisis severity.
- Supports the hypothesis that leukemic blasts increase ferritin synthesis during blastic crisis.
- Normal ferritin levels in remission post-bone marrow transplant indicate successful treatment.